2-Butyloxy-3,5-di-tert-butylphenylboronic acid → 3-(3',5'-di-tert-butyl-6-hydroxy-2'-butyloxy-3-biphenylyl)acrylic Acid
Reaction equation
Br[C:2]1[CH:3]=[C:4]([CH:9]=[CH:10][C:11]([O:13]CC)=[O:12])[CH:5]=[CH:6][C:7]=1[OH:8].[CH2:16]([O:20][C:21]1[C:26]([C:27]([CH3:30])([CH3:29])[CH3:28])=[CH:25][C:24]([C:31]([CH3:34])([CH3:33])[CH3:32])=[CH:23][C:22]=1B(O)O)[CH2:17][CH2:18][CH3:19]>>[C:27]([C:26]1[C:21]([O:20][CH2:16][CH2:17][CH2:18][CH3:19])=[C:22]([C:2]2[C:7]([OH:8])=[CH:6][CH:5]=[C:4]([CH:9]=[CH:10][C:11]([OH:13])=[O:12])[CH:3]=2)[CH:23]=[C:24]([C:31]([CH3:34])([CH3:33])[CH3:32])[CH:25]=1)([CH3:30])([CH3:29])[CH3:28]Participants
3
Procedure
In a manner similar to that of Example 1(c), by reaction of 6.2 g (22.8 mmol) of ethyl 3-(3-bromo-4-hydroxyphenyl)acrylate obtained in Example 34(d) with 14 g (45.7 mmol) of 2-butyloxy-3,5-di-tert-butylphenylboronic acid obtained above, 700 mg (7%) of the expected compound were obtained in the form of a yellow oil.
Sources & evidence
- ORD record
- ord-d1b56e3bb4964a83b2daccea9360f228
- Source dataset
- uspto-grants-2003_10
- Patent number
- US06632963B1
Reaction notes
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