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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 988147Generated: October 30, 2026

5-Methyl-1H-imidazole-4-carbaldehyde → HCID 178433224, compound

https://huagongshe.com/reaction/988147

Reaction equation

Participants

RoleNameHCIDCharge
Reactant5-Methyl-1H-imidazole-4-carbaldehydeHCID 2795887—
Reactant4-Pyridin-4-yl-1,3-dihydro-indol-2-oneHCID 12111581—
CatalystPiperidineHCID 8082—
SolventEthanolHCID 702—
ProductHCID 178433224HCID 17843322410.7%

Reaction Steps

A mixture of 4-pyridin-4-yl-1,3-dihydroindol-2-one (50 mg, 0.24 mmol), 5-methyl-3H-imidazole-4-carbaldehyde (24.4 mg, 0.24 mmol) and piperidine (1 drop) in ethanol (2 mL) was stirred at room temperature for 2 days. The precipitate which formed was filtered. Crystals which formed in the filtrate were isolated, washed with ethanol and dried to give 7.8 mg of the title compound.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS06635640B2
Source datasetuspto-grants-2003_10
ORD IDord-6992c1d77eb849498f8887999c10896b
Source noteuspto-grants-2003_10