5-Methyl-1H-imidazole-4-carbaldehyde → HCID 178433224, compound

HRID 988147Notes

Reaction equation

HRID 988147 reaction equation
[N:1]1[CH:6]=[CH:5][C:4]([C:7]2[CH:15]=[CH:14][CH:13]=[C:12]3[C:8]=2[CH2:9][C:10](=[O:16])[NH:11]3)=[CH:3][CH:2]=1.[CH3:17][C:18]1[N:22]=[CH:21][NH:20][C:19]=1[CH:23]=O>N1CCCCC1.C(O)C>[CH3:17][C:18]1[N:22]=[CH:21][NH:20][C:19]=1[CH:23]=[C:9]1[C:8]2[C:12](=[CH:13][CH:14]=[CH:15][C:7]=2[C:4]2[CH:5]=[CH:6][N:1]=[CH:2][CH:3]=2)[NH:11][C:10]1=[O:16]

Participants

5

Reactant 2

HCID 27958875-Methyl-1H-imidazole-4-carbaldehydeHCID 121115814-Pyridin-4-yl-1,3-dihydro-indol-2-one

Product 1

HCID 178433224HCID 178433224, compoundYield 10.7%

Reagents, catalysts & solvents 2

HCID 8082PiperidineCatalystHCID 702EthanolSolvent

Procedure

A mixture of 4-pyridin-4-yl-1,3-dihydroindol-2-one (50 mg, 0.24 mmol), 5-methyl-3H-imidazole-4-carbaldehyde (24.4 mg, 0.24 mmol) and piperidine (1 drop) in ethanol (2 mL) was stirred at room temperature for 2 days. The precipitate which formed was filtered. Crystals which formed in the filtrate were isolated, washed with ethanol and dried to give 7.8 mg of the title compound.

Workup

  1. customThe precipitate which formed
  2. filtrationwas filtered
  3. customCrystals which formed in the filtrate
  4. customwere isolated
  5. washwashed with ethanol
  6. customdried

Sources & evidence

ORD record
ord-6992c1d77eb849498f8887999c10896b
Source dataset
uspto-grants-2003_10
Patent number
US06635640B2

Reaction notes

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