Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Piperidine | HCID 8082 | — |
| Reactant | 3,5-dimethyl-4-(4-methylpiperazine-1-carbonyl)-1H-pyrrole-2-carbaldehyde | HCID 12111582 | — |
| Reactant | 4-Pyridin-3-yl-1,3-dihydroindol-2-one | HCID 22135407 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | HCID 69584126 | HCID 69584126 | — |
Reaction Steps
A mixture of 4-pyridin-3-yl-1,3-dihydroindol-2-one (42 mg, 0.2 mmol), 3,5-dimethyl-4-(4-methylpiperazine-1-carbonyl)-1H-pyrrole-2-carbaldehyde (50 mg, 0.2 mmol) and piperidine (0.1 mL) in ethanol was heated in a sealed tube at 70° C. for 5 hours. The reaction was concentrated and the residue was crystallized from ethyl acetate/hexane to give the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US06635640B2 |
|---|
| Source dataset | uspto-grants-2003_10 |
|---|
| ORD ID | ord-7856349cdc5240b586fb1b51dd352930 |
|---|
| Source note | uspto-grants-2003_10 |
|---|
