Sodium Hydroxide → HCID 18008023, compound

HRID 988222Notes

Reaction equation

HRID 988222 reaction equation
C[O:2][C:3]([C:5]1[CH:32]=[CH:31][C:8]([CH2:9][C:10]2([CH2:20][C:21]3[CH:26]=[CH:25][C:24]([C:27]([O:29]C)=[O:28])=[CH:23][CH:22]=3)[N:14]3[CH:15]=[CH:16][CH:17]=[CH:18][C:13]3=[N:12][C:11]2=[O:19])=[CH:7][CH:6]=1)=[O:4].[OH-].[Na+]>C(O)C>[C:3]([C:5]1[CH:6]=[CH:7][C:8]([CH2:9][C:10]2([CH2:20][C:21]3[CH:22]=[CH:23][C:24]([C:27]([OH:29])=[O:28])=[CH:25][CH:26]=3)[N:14]3[CH:15]=[CH:16][CH:17]=[CH:18][C:13]3=[N:12][C:11]2=[O:19])=[CH:31][CH:32]=1)([OH:4])=[O:2]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 18008013HCID 18008013, compound

Product 1

HCID 18008023HCID 18008023, compoundYield 71%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

300 mg (0.7 mmol) of 3,3-bis(4-methoxycarbonylbenzyl)-imidazo[1,2-a]pyridin-2(3H)-one prepared in the similar way to that of Example 1 was heated at 70° C. for 3 hours in a mixture of 8 ml of 2N-sodium hydroxide and 2 ml of ethanol. The reaction mixture was allowed to cool to room temperature and washed with methylene chloride. The water layer was adjusted by diluted hydrochloric acid to pH5 and the precipitated deposit was filtered out and dried, thus obtaining 200 mg (yield: 71%) of the titled compound.

Workup

  1. washwashed with methylene chloride
  2. filtrationthe precipitated deposit was filtered out
  3. customdried

Sources & evidence

ORD record
ord-9d1a9a397e834e3a9fac2bc575281ea4
Source dataset
uspto-grants-2003_10
Patent number
US06635652B1

Reaction notes

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