Sodium Hydroxide → HCID 18008023, compound

Participants

Reaction Steps

300 mg (0.7 mmol) of 3,3-bis(4-methoxycarbonylbenzyl)-imidazo[1,2-a]pyridin-2(3H)-one prepared in the similar way to that of Example 1 was heated at 70° C. for 3 hours in a mixture of 8 ml of 2N-sodium hydroxide and 2 ml of ethanol. The reaction mixture was allowed to cool to room temperature and washed with methylene chloride. The water layer was adjusted by diluted hydrochloric acid to pH5 and the precipitated deposit was filtered out and dried, thus obtaining 200 mg (yield: 71%) of the titled compound.

Provenance & Evidence