2-Chloropropionic acid → N-(3,5-difluorophenyl)alanine

HRID 988459Notes

Reaction equation

HRID 988459 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([CH:6]=[C:7]([F:9])[CH:8]=1)[NH2:5].Cl[CH:11]([CH3:15])[C:12]([OH:14])=[O:13]>>[F:1][C:2]1[CH:3]=[C:4]([NH:5][C@H:11]([C:12]([OH:14])=[O:13])[CH3:15])[CH:6]=[C:7]([F:9])[CH:8]=1

Participants

3

Reactant 2

HCID 117342-Chloropropionic acidHCID 965953,5-Difluoroaniline

Product 1

HCID 53936901N-(3,5-difluorophenyl)alanine

Procedure

Using the procedure set forth in U.S. Pat. No. 3,598,859, N-(3,5-difluorophenyl)alanine was prepared using 3,5-difluoroaniline (Aldrich) and 2-chloropropionic acid (Aldrich).

Sources & evidence

ORD record
ord-f646e9a4c18b42c9b3cd97c433edf2b5
Source dataset
uspto-grants-2003_10
Patent number
US06635632B1

Reaction notes

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