Hydrochloric Acid → HCID 21906176, compound

HRID 988704Notes

Reaction equation

HRID 988704 reaction equation
Cl.[C:2](N)(=O)[C:3]1C=CC=C[CH:4]=1.FC(F)(F)C(O)=O.[C:18]([C:21]1[CH:22]=[CH:23][C:24]([NH:37][C:38]([CH:40]2[CH2:45][CH2:44][NH:43][CH2:42][CH2:41]2)=[O:39])=[C:25]([CH:36]=1)[C:26]([NH:28][C:29]1[CH:34]=[CH:33][C:32]([Cl:35])=[CH:31][N:30]=1)=[O:27])(=[O:20])[CH3:19].Cl>ClCCl.C(OCC)C>[ClH:35].[C:18]([C:21]1[CH:22]=[CH:23][C:24]([NH:37][C:38]([CH:40]2[CH2:41][CH2:42][N:43]([CH:3]([CH3:4])[CH3:2])[CH2:44][CH2:45]2)=[O:39])=[C:25]([CH:36]=1)[C:26]([NH:28][C:29]1[CH:34]=[CH:33][C:32]([Cl:35])=[CH:31][N:30]=1)=[O:27])(=[O:20])[CH3:19]

Participants

6

Reactant 3

HCID 313Hydrochloric AcidHCID 12196675Benzamide, hydrochlorideHCID 21906551HCID 21906551, compound

Product 1

HCID 21906176HCID 21906176, compound

Reagents, catalysts & solvents 2

HCID 3283Diethyl EtherSolventHCID 6344DichloromethaneSolvent

Procedure

Using methods substantially equivalent to those described in Example 244-F, 5-acetyl-N-(5-chloropyridin-2-yl)-2-(1-isopropylpiperidin-4-ylcarbonyl)amino]benzamide hydrochloride (48 mg, 67%) was prepared from 5-acetyl-N-(5-chloropyridin-2-yl)-2-[(4-piperidinylcarbonyl)amino]-benzamide trifluoroacetate. To a stirring solution of the purified product in dichloromethane was added 1.0 N hydrochloric acid in diethyl ether until precipitate formed. The mixture was filtered to give the title compound.

Workup

  1. customformed
  2. filtrationThe mixture was filtered

Sources & evidence

ORD record
ord-7fe512f8431d4b8bb7f17f9a6a1340d3
Source dataset
uspto-grants-2003_10
Patent number
US06635657B1

Reaction notes

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