4-Chloropyridine hydrochloride → HCID 21906494, compound

HRID 988725Notes

Reaction equation

HRID 988725 reaction equation
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([NH:8][C:9](=[O:28])[C:10]2[CH:15]=[C:14]([C:16]([O:18][CH3:19])=[O:17])[CH:13]=[CH:12][C:11]=2[NH:20][CH2:21][CH:22]2[CH2:27][CH2:26][NH:25][CH2:24][CH2:23]2)=[N:6][CH:7]=1.Cl.Cl[C:31]1[CH:36]=[CH:35][N:34]=[CH:33][CH:32]=1>>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([NH:8][C:9](=[O:28])[C:10]2[CH:15]=[C:14]([C:16]([O:18][CH3:19])=[O:17])[CH:13]=[CH:12][C:11]=2[NH:20][CH2:21][CH:22]2[CH2:27][CH2:26][N:25]([C:31]3[CH:36]=[CH:35][N:34]=[CH:33][CH:32]=3)[CH2:24][CH2:23]2)=[N:6][CH:7]=1

Participants

3

Reactant 2

HCID 818524-Chloropyridine hydrochlorideHCID 21906567HCID 21906567, compound

Product 1

HCID 21906494HCID 21906494, compound

Procedure

Using a similar procedure to that described in Example 52, N-(5-chloropyridin-2-yl)-5-methoxycarbonyl-2-[(4-piperidinylmethyl)amino]benzamide (0.30 g, 0.74 mmol) and 4-chloropyridine hydrochloride (0.22 g, 1.5 mmol) afforded, after purification by ion-exchange chromatography (SCX), 260 mg (73%) of the title compound.

Workup

  1. customafforded
  2. customafter purification by ion-exchange chromatography (SCX), 260 mg (73%) of the title compound

Sources & evidence

ORD record
ord-f0d2292f54dd4f74af5f7cd4702ef18f
Source dataset
uspto-grants-2003_10
Patent number
US06635657B1

Reaction notes

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