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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 988839Generated: October 29, 2026

Hydrogen Bromide → Citalopram Hydrobromide

https://huagongshe.com/reaction/988839

Reaction equation

Participants

RoleNameHCIDCharge
ReactantHydrogen BromideHCID 260—
ReactantCitalopramHCID 2771—
SolventEthyl AcetateHCID 8857—
ProductCitalopram HydrobromideHCID 7799590%

Reaction Conditions

Temperature7.5 °C

Reaction Steps

A total of 8.2 g of 62% hydrobromic acid is added to a solution of 20 g of citalopram in 120 ml of ethyl acetate. The mixture is cooled to 5-10° C. and left to crystallise. The crystals formed are filtered off and dried. A total of 22.5 g (yield: 90%) of citalopram hydrobromide are obtained.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS06635773B2
Source datasetuspto-grants-2003_10
ORD IDord-e91ce76d2b7b4f0ba9bdd96d091b1479
Source noteuspto-grants-2003_10