HRID988839

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID260

Hydrogen Bromide

BrH

结构：CN(C)CCCC1(c2ccc(F)cc2)OCc2cc(C#N)ccc21

HCID2771

Citalopram

C20H21FN2O

PRODUCTS

生成物

结构：Br.CN(C)CCCC1(c2ccc(F)cc2)OCc2cc(C#N)ccc21

HCID77995

Citalopram hydrobromide

C20H22BrFN2O

收率 90%

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID8857

Ethyl acetate

C4H8O2

CONDITIONS

反应条件

温度: 7.5 °C

PROCEDURE

实验过程

A total of 8.2 g of 62% hydrobromic acid is added to a solution of 20 g of citalopram in 120 ml of ethyl acetate. The mixture is cooled to 5-10° C. and left to crystallise. The crystals formed are filtered off and dried. A total of 22.5 g (yield: 90%) of citalopram hydrobromide are obtained.

WORKUP

后处理

waitleft
customto crystallise
customThe crystals formed
filtrationare filtered off
customdried