HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sulfuric Acid → (+/-)-(2-chlorophenyl)-(6,7-dihydro-4H-thieno[3,2-c]pyrid-5-yl)acetamide Hydrogen Sulfate Salt
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sulfuric Acid | HCID 1118 | — |
| Reactant | Diethyl Ether | HCID 3283 | — |
| Reactant | 2-Chlorophenyl-(6,7-dihydro-4H-thieno[3,2-c]pyridin-5-yl)acetamide | HCID 11312824 | — |
| Reactant | rac-2-(2-Chlorophenyl)-(6,7-dihydro-4H-thieno[3,2-c]pyridin-5-yl)acetonitrile | HCID 11369741 | — |
| Solvent | Acetone | HCID 180 | — |
| Product | (+/-)-(2-chlorophenyl)-(6,7-dihydro-4H-thieno[3,2-c]pyrid-5-yl)acetamide Hydrogen Sulfate Salt | HCID 86586489 | 76% |
Reaction Steps
2 g (6.48 mole) of (±)-(2-chlorophenyl)-(6,7-dihydro-4H-thieno[3,2-c]pyrid-5-yl)acetamide of formula (IV), was dissolved in 10 mL acetone. To the reaction mixture 1 mL of sulfuric acid was added and was stirred for 0.5 hr. Later 5 mL of diethyl ether was added and stirred overnight at room temperature to obtain a salt. The salt 2 g (76%) was isolated by filtration and washed with acetone.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06635763B2 |
| Source dataset | uspto-grants-2003_10 |
| ORD ID | ord-53520a5eed82450c94808a347a3400f6 |
| Source note | uspto-grants-2003_10 |