Sulfuric Acid → Clopidogrel hydrogen sulfate

Participants

Reaction Steps

10 g of (+) Methyl (2-chlorophenyl)-(6,7-dihydro-4H-thieno[3,2-c]pyrid-5-yl)acetate prepared according to Example 22, was dissolved in 100 mL of ice-cold acetone and 2 mL concentrated sulfuric acid was added at 0° C. to 5° C. The crystalline white to off white product formed was isolated by filtration and washed with 20 mL of acetone. The product obtained was dried in vacuum oven at 50° C. The yield of titled product was 7.2 g (56%).

Provenance & Evidence