Hydrochloric Acid → HCID 18008545, compound

HRID 988865Notes

Reaction equation

HRID 988865 reaction equation
[CH3:1][NH:2][C:3]12[CH2:9][CH:6]([CH2:7][CH2:8]1)[CH:5]([OH:10])[CH2:4]2.[ClH:11]>C(O)C>[ClH:11].[CH3:1][NH:2][C:3]12[CH2:9][CH:6]([CH2:7][CH2:8]1)[CH:5]([OH:10])[CH2:4]2

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 18008537HCID 18008537, compound

Product 1

HCID 18008545HCID 18008545, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent2×

Procedure

0.4 g of A3 are dissolved in 4 ml of ethanol and mixed at room temperature with 4 ml of 15% HCl in ethanol. After concentrating by evaporation on a rotary evaporator, a white solid is obtained (0.44 g), which is recrystallised from 2 ml of isopropanol. The title compound A4 is thus obtained as a white solid (0.2 g, 40%). Melting point 154° C. 1H-NMR (400 Hz, DMSOd6) δ: 1.13 (1H); 1.38 (3H); 2.05 (2H); 2.25 (1H); 2.52 (3H); 3.43 (1H); 4.35 (1H); 5.92 (1H); 8.57 (2H).

Workup

  1. concentrationAfter concentrating by evaporation on a rotary evaporator
  2. customa white solid is obtained (0.44 g), which
  3. customis recrystallised from 2 ml of isopropanol

Sources & evidence

ORD record
ord-36eee93a58724f10b1c55f0c1e274da7
Source dataset
uspto-grants-2003_10
Patent number
US06635783B2

Reaction notes

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