反应详情

To (6-chloro-1H-indol-2-yl)-methanol (37.7 mmol) in THF at 0° C. was added manganese (IV) oxide and the mixture was stirred at rt for 16 h. The mixture was filtered over celite and rinsed with THF and EtOAc and evaporated to near dryness. The solid was filtered and washed with cold EtOAc/hex to give 6-Chloro-1H-indole-2-carbaldehyde (62%, 2 steps).

1. filtrationThe mixture was filtered over celite
2. washrinsed with THF and EtOAc
3. customevaporated
4. filtrationThe solid was filtered
5. washwashed with cold EtOAc/hex