(3,4-Dichlorophenyl)methanesulfonyl chloride → 4-[{2-[1-benzhydryl-5-chloro-2-(2-{[(3,4-dichlorobenzyl)sulfonyl]amino}ethyl)-1H-indol-3-yl]ethyl}(methyl)amino]benzoic Acid

Participants

Role	Name	HCID	Charge
Reactant	(3,4-Dichlorophenyl)methanesulfonyl chloride	HCID 2794622	—
Reactant	4-({2-[2-(2-Amino-ethyl)-1-benzhydryl-5-chloro-1H-indol-3-yl]-ethyl}methyl-amino)-benzoic acid methyl ester	HCID 20598525	—
Product	4-[{2-[1-benzhydryl-5-chloro-2-(2-{[(3,4-dichlorobenzyl)sulfonyl]amino}ethyl)-1H-indol-3-yl]ethyl}(methyl)amino]benzoic Acid	HCID 21962384	87%

Reaction Steps

The intermediate from example 146 step 7 was treated with 3,4-dichlorophenylmethanesulfonylchloride according to the procedure in Example 87 step 2 to generate the desired product in 87% yield.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US06635771B2
Source dataset	uspto-grants-2003_10
ORD ID	ord-c889b974a87d4c79968147d2c09825dc
Source note	uspto-grants-2003_10