p-Fluoronitrobenzene → HCID 18003915, compound

HRID 988924Notes

Reaction equation

HRID 988924 reaction equation
F[C:2]1[CH:7]=[CH:6][C:5]([N+:8]([O-:10])=[O:9])=[CH:4][CH:3]=1.[NH2:11][CH:12]([CH2:15][CH3:16])[CH2:13][OH:14].C(=O)([O-])[O-].[K+].[K+]>O>[N+:8]([C:5]1[CH:6]=[CH:7][C:2]([NH:11][CH:12]([CH2:15][CH3:16])[CH2:13][OH:14])=[CH:3][CH:4]=1)([O-:10])=[O:9]

Participants

5

Reactant 3

HCID 9590p-FluoronitrobenzeneHCID 11430Potassium CarbonateHCID 221292-Amino-1-butanol

Product 1

HCID 18003915HCID 18003915, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

A mixture of 223.0 g (1.58 mol) of 1-fluoro-4-nitrobenzene, 168.5 g (1.89 mol) of 2-amino-1-butanol and 146.8 g (1.06 mol) of potassium carbonate in 630 ml of water was refluxed for 2 hours.

Workup

  1. temperaturewas refluxed for 2 hours

Sources & evidence

ORD record
ord-922d7562faca4debae1a135d105e7bef
Source dataset
uspto-grants-2003_10
Patent number
US06638321B1

Reaction notes

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