Hydrochloric Acid → HCID 22250932, compound

HRID 988968Notes

Reaction equation

HRID 988968 reaction equation
O[N:2]=[C:3]1[CH2:8][CH2:7][CH2:6][CH2:5][CH:4]1[O:9][CH3:10].[ClH:11]>[Ni].C(O)C>[ClH:11].[CH3:10][O:9][CH:4]1[CH2:5][CH2:6][CH2:7][CH2:8][CH:3]1[NH2:2]

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 737992461-(Hydroxyimino)-2-methoxycyclohexane

Product 1

HCID 22250932HCID 22250932, compound

Reagents, catalysts & solvents 2

HCID 935NickelCatalystHCID 702EthanolSolvent

Procedure

A mixture of 1-(hydroxyimino)-2-methoxycyclohexane (1.05 mmol) and Raney Nickel (0.5 g) in ethanol (30 mL) was hydrogenated (90 psi) at room temperature for 2 days. The mixture was filtered through a pad of Celite, washed with MeOH, and concentrated. The residue was dissolved in MeOH, treated with HCl (4 N in dioxane, 4 mmol), and concentrated to give 2-methoxycyclohexylamine hydrochloride.

Workup

  1. customat room temperature
  2. customfor 2 days
  3. filtrationThe mixture was filtered through a pad of Celite
  4. washwashed with MeOH
  5. concentrationconcentrated
  6. dissolutionThe residue was dissolved in MeOH
  7. concentrationconcentrated

Sources & evidence

ORD record
ord-73dd61579cbd411a92239f81a1ea1c9e
Source dataset
uspto-grants-2003_10
Patent number
US06638927B2

Reaction notes

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