反应详情

A mixture of 1-(hydroxyimino)-4-phenylcyclohexane (17.4 mmol) and Raney Nickel (300 mg) in ethanol was hydrogenated (90 psi) at 50° C. for 40 hours. The mixture was filtered through a pad of Celite, washed with MeOH, and concentrated. The residue was dissolved in MeOH, treated with HCl (4 N in dioxane, 20 mmol), and concentrated to give 4-phenylcyclohexylamine hydrochloride (100%).

1. customat 50° C.
2. customfor 40 hours
3. filtrationThe mixture was filtered through a pad of Celite
4. washwashed with MeOH
5. concentrationconcentrated
6. dissolutionThe residue was dissolved in MeOH
7. concentrationconcentrated