Methanol → Methyl 2-aminoisobutyrate hydrochloride

HRID 988979Notes

Reaction equation

[NH2:1][C:2]([CH3:7])([CH3:6])[C:3]([OH:5])=[O:4].S(Cl)([Cl:10])=O.[CH3:12]O>>[ClH:10].[CH3:12][O:4][C:3](=[O:5])[C:2]([NH2:1])([CH3:7])[CH3:6]

Participants

Reactant 3

HCID 887Methanol

HCID 6119Aminoisobutyric acid

HCID 24386Thionyl Chloride

Product 1

HCID 13258034Methyl 2-aminoisobutyrate hydrochlorideYield 97.4%

Procedure

This was synthesised according to Standard Procedure 1, using 2-amino-isobutyric acid (4 g, 0.039 mol) with thionyl chloride (5.66 ml, 0.078 mol) and anhydrous methanol (23.5 ml, 0.58 mol). This gave the product as a white solid (5.805 g, 97.4%)

Workup

customThis was synthesised

Sources & evidence

ORD record: ord-dd5d06c2ffff4c789cbefa6557f8ad32
Source dataset: uspto-grants-2003_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06638919B2

Reaction notes

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