Chloride → HCID 90044568, compound

Tionyl chloride (1.6 ml, 0.022 M) was added dropwise to a stirred solution of 3-pentanol (18.2 ml, 0.17 M) at 0° C. under nitrogen. The mixture was stirred for 30 minutes, then allowed to warm to room temperature. L-Alanine (pre-dried at 60° C. over P2O5 for 4 hrs: 1.0 g, 0.011 M) was added and the resulting suspension was heated at reflux overnight (the reaction mixture became a clear, colourless solution). The solvent was removed under reduced pressure to leave an oil which was repeatedly triturated and coevaporated with diethyl ether, then petrol (60/80) to remove traces of 3-pentanol. The resulting oily residue solidified on drying under high vacuum to give a peach-coloured solid (1.96 g, 10 mmol, 89%).

1. temperaturethe resulting suspension was heated
2. temperatureat reflux overnight (the reaction mixture
3. customThe solvent was removed under reduced pressure
4. customto leave an oil which
5. customwas repeatedly triturated
6. custompetrol (60/80) to remove traces of 3-pentanol
7. customon drying under high vacuum

ORD record

ord-e74a4653d52b4ea0b5229a93da107fb9

Source dataset

uspto-grants-2003_10

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US06638919B2