2-Aminopyrimidine → HCID 9795705, compound

HRID 988995Notes

Reaction equation

HRID 988995 reaction equation
[NH2:1][C:2]1[N:7]=[CH:6][CH:5]=[CH:4][N:3]=1.[CH2:8]([N+:12]#[C-:13])[CH2:9][CH2:10][CH3:11].[CH3:14][C:15]1[CH:22]=[CH:21][CH:20]=[CH:19][C:16]=1[CH:17]=O>Cl(O)(=O)(=O)=O>[CH2:8]([NH:12][C:13]1[N:3]2[CH:4]=[CH:5][CH:6]=[N:7][C:2]2=[N:1][C:14]=1[C:15]1[CH:22]=[CH:21][CH:20]=[CH:19][C:16]=1[CH3:17])[CH2:9][CH2:10][CH3:11]

Participants

5

Reactant 3

HCID 79782-AminopyrimidineHCID 107222-MethylbenzaldehydeHCID 76008Butyl isocyanide

Product 1

HCID 9795705HCID 9795705, compound

Reagents, catalysts & solvents 1

HCID 24247Perchloric AcidSolvent

Procedure

Compound (16) was prepared in accordance with general instructions 1 from 1.0 ml 2-aminopyrimidine solution (0.1 M, MC), 0.575 ml n-butylisonitrile solution (0.2 M, MC), 0.500 ml 2-methylbenzaldehyde solution (0.3 M, MC), and 10 μl perchloric acid (w=20%).

Sources & evidence

ORD record
ord-864c8a5c82ee424e9a3573e7d3fc4e96
Source dataset
uspto-grants-2003_10
Patent number
US06638933B2

Reaction notes

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