HuagongsheHuagongshe Chemistry Print Report · For research reference only
Isocyanate → HCID 10573917, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Isocyanate | HCID 105034 | — |
| Reactant | 5-Methoxy-6-(trifluoromethyl)indoline | HCID 11206713 | — |
| Reactant | 5-Bromopyridine-3-carbonyl azide | HCID 15622850 | — |
| Solvent | Toluene | HCID 1140 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | HCID 10573917 | HCID 10573917 | 81% |
Reaction Steps
5-Bromo-3-pyridylcarbonylazide (3.7 g, 16 mmoles) was heated under reflux in dry toluene (100 ml) for 1 hr. After cooling the resulting solution of isocyanate was treated with a solution of 5-methoxy-6-trifluoromethyl indoline (D11) (35 g, 16 mmoles) in dichloromethane (600 ml) and stirred overnight. The mixture was concentrated in vacuo and the residue triturated with diethyl ether. Filtration and washing with more diethyl ether gave the tide compound (D26) (5.4 g, 81%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06638953B2 |
| Source dataset | uspto-grants-2003_10 |
| ORD ID | ord-a2feb5a794c44f17a29ac5581d70049c |
| Source note | uspto-grants-2003_10 |