5-Bromopyrimidine → 3-Pyrimidin-5-ylaniline

HRID 989174Notes

Reaction equation

Br[C:2]1[CH:3]=[N:4][CH:5]=[N:6][CH:7]=1.[NH2:8][C:9]1[CH:10]=[C:11](B(O)O)[CH:12]=[CH:13][CH:14]=1>>[N:4]1[CH:3]=[C:2]([C:13]2[CH:14]=[C:9]([CH:10]=[CH:11][CH:12]=2)[NH2:8])[CH:7]=[N:6][CH:5]=1

Participants

Reactant 2

HCID 783445-Bromopyrimidine

HCID 922693-Aminophenylboronic acid

Product 1

HCID 71620493-Pyrimidin-5-ylanilineYield 84%

Procedure

This was prepared from 5-bromopyrimidine and 3-aminophenyl boronic acid in 84% yield by the same method as for Description 12.

Sources & evidence

ORD record: ord-2cb8dd6a46a9477bb07ad26b0d848acb
Source dataset: uspto-grants-2003_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06638953B2

Reaction notes

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