HuagongsheHuagongshe Chemistry Print Report · For research reference only
5-Methoxy-6-(trifluoromethyl)indoline → 5-Methoxy-6-trifluoromethyl-1-[4-(pyridin-4-ylthiomethyl)phenyl Carbamoyl]indoline
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 5-Methoxy-6-(trifluoromethyl)indoline | HCID 11206713 | — |
| Reactant | Benzenamine, 4-[(4-pyridinylthio)methyl]- | HCID 18005148 | — |
| Reactant | Phenylcarbamate | HCID 21896570 | — |
| Product | 5-Methoxy-6-trifluoromethyl-1-[4-(pyridin-4-ylthiomethyl)phenyl Carbamoyl]indoline | HCID 18005150 | 64% |
Reaction Steps
4-(Pyridin-4-ylthiomethyl)aniline (0.37 g, 1.71 mmol) was converted to the phenylcarbamate and treated with 5-methoxy-6-trifluoromethylindoline (D11) (0.37 g, 1.71 mmol) as in the method of Example 26 to give the title compound (0.5 g, 64%) as a white crystalline solid m.p. 174-5° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06638953B2 |
| Source dataset | uspto-grants-2003_10 |
| ORD ID | ord-342b1da1f8b54a13bce21db6ceb7dc27 |
| Source note | uspto-grants-2003_10 |