反应详情

2.5 ml of H2O and then 4.23 g (16.1 mmol) of triphenylphosphine PPh3 are added to a solution of the compound obtained in Step D (2.4 g/10.73 mmol) in 60 ml of THF, and then the reaction mixture is stirred at room temperature overnight. The whole is then concentrated to dryness and subsequently chromatographed over silica gel (CH2Cl2, 20% MeOH, 2% NH4OH) to yield the title product in the form of a yellowish oil.

1. concentrationThe whole is then concentrated to dryness
2. customsubsequently chromatographed over silica gel (CH2Cl2, 20% MeOH, 2% NH4OH)