Water → HCID 12015904, compound

HRID 989261Notes

Reaction equation

HRID 989261 reaction equation
O.C1(P(C2C=CC=CC=2)C2C=CC=CC=2)C=CC=CC=1.C1C=CC(P(C2C=CC=CC=2)C2C=CC=CC=2)=CC=1.[N:40]([CH:43]1[CH2:49][CH2:48][CH2:47][CH2:46][C:45]([C:50]2[CH:55]=[CH:54][CH:53]=[CH:52][C:51]=2[CH3:56])=[CH:44]1)=[N+]=[N-]>C1COCC1>[CH3:56][C:51]1[CH:52]=[CH:53][CH:54]=[CH:55][C:50]=1[C:45]1[CH2:46][CH2:47][CH2:48][CH2:49][CH:43]([NH2:40])[CH:44]=1

Participants

5

Reactant 3

HCID 962WaterHCID 12015903HCID 12015903, compoundHCID 86586183HCID 86586183, compound

Product 1

HCID 12015904HCID 12015904, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

2.5 ml of H2O and then 4.23 g (16.1 mmol) of triphenylphosphine PPh3 are added to a solution of the compound obtained in Step D (2.4 g/10.73 mmol) in 60 ml of THF, and then the reaction mixture is stirred at room temperature overnight. The whole is then concentrated to dryness and subsequently chromatographed over silica gel (CH2Cl2, 20% MeOH, 2% NH4OH) to yield the title product in the form of a yellowish oil.

Workup

  1. concentrationThe whole is then concentrated to dryness
  2. customsubsequently chromatographed over silica gel (CH2Cl2, 20% MeOH, 2% NH4OH)

Sources & evidence

ORD record
ord-e97f0b4818014e518a017036407d3209
Source dataset
uspto-grants-2003_10
Patent number
US06638962B2

Reaction notes

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