Pyrrolidine → HCID 9878079, compound

HRID 989267Notes

Reaction equation

HRID 989267 reaction equation
Cl[CH2:2][C:3]1[CH:14]=[CH:13][C:6]([CH2:7][N:8]2[CH:12]=[CH:11][CH:10]=[CH:9]2)=[CH:5][CH:4]=1.[NH:15]1[CH2:19][CH2:18][CH2:17][CH2:16]1>>[N:15]1([CH2:2][C:3]2[CH:14]=[CH:13][C:6]([CH2:7][N:8]3[CH:12]=[CH:11][CH:10]=[CH:9]3)=[CH:5][CH:4]=2)[CH2:19][CH2:18][CH2:17][CH2:16]1

Participants

3

Reactant 2

HCID 31268PyrrolidineHCID 155859181-{[4-(Chloromethyl)phenyl]methyl}-1H-pyrrole

Product 1

HCID 9878079HCID 9878079, compound

Procedure

The title compound was prepared starting from 1-(4-chloromethyl-benzyl)-pyrrole (preparation in example 20 step A) and pyrrolidine by the same method reported in Example 19 step B. 1H NMR (400 MHz, MeOD-d4)δ7.26 (m, 2 H), 7.15 (m, 2 H), 7.05 (m, 2 H), 6.85 (m, 2 H), 6.57 (t, J=2.1 Hz, 2 H), 5.96 (t, J=2.1 Hz, 2 H), 4.98 (s, 2 H), 4.92 (s, 2 H), 3.50 (s, 3 H), 2.50 (m, 2 H), 1.70 (m, 2 H).

Sources & evidence

ORD record
ord-8d335a2c92804c1ba14097087a311a64
Source dataset
uspto-grants-2003_10
Patent number
US06638967B2

Reaction notes

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