Thionyl Chloride → HCID 16495035, compound

HRID 989272Notes

Reaction equation

HRID 989272 reaction equation
[N:1]1([CH2:6][C:7]2[CH:12]=[CH:11][C:10]([CH2:13]O)=[CH:9][CH:8]=2)[CH2:5][CH2:4][CH2:3][CH2:2]1.S(Cl)([Cl:17])=O>C(Cl)Cl>[Cl:17][CH2:13][C:10]1[CH:11]=[CH:12][C:7]([CH2:6][N:1]2[CH2:5][CH2:4][CH2:3][CH2:2]2)=[CH:8][CH:9]=1

Participants

4

Reactant 2

HCID 24386Thionyl ChlorideHCID 16495034{4-[(Pyrrolidin-1-yl)methyl]phenyl}methanol

Product 1

HCID 16495035HCID 16495035, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

A solution of the product of Step C in DCM (200 mL) was treated with thionyl chloride (20 mL) at 40° C. for 16 hours. Solvent was removed in vacuo to give the titled compound (15 g), which was used without purification.

Workup

  1. customSolvent was removed in vacuo

Sources & evidence

ORD record
ord-c2fe768ad721481a83c81c09dfad51ef
Source dataset
uspto-grants-2003_10
Patent number
US06638967B2

Reaction notes

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