反应详情

A mixture of ethyl 7-hydroxy-chroman-2-carboxylate (6.1 g, 27.5 mmol), potassium carbonate (7.6 g, 55 mmol), potassium iodide (1.8 g, 11 mmol) and benzyl chloride (3.4 mL, 30 mmol) in acetone is heated at reflux for 16 hr under nitrogen, cooled, concentrated, diluted with water and extracted with EtOAc. The combined extracts are dried over MgSO4 and concentrated to afford the title compound as a straw-colored oil 8.58 g (100% yield), identified by NMR and mass spectral analyses.

1. temperatureis heated
2. temperatureat reflux for 16 hr under nitrogen
3. temperaturecooled
4. concentrationconcentrated
5. additiondiluted with water
6. extractionextracted with EtOAc
7. dry with materialThe combined extracts are dried over MgSO4
8. concentrationconcentrated