HCID 21956470, compound → HCID 69372248, compound

HRID 989310Notes

Reaction equation

HRID 989310 reaction equation
[NH2:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][C:11]=1[NH:12][C:13](=O)[CH2:14][Cl:15])[N:8]=[CH:7][C:6]([C:17]#[N:18])=[C:5]2[NH:19][C:20]1[CH:25]=[C:24]([O:26][CH3:27])[C:23]([O:28][CH3:29])=[C:22]([O:30][CH3:31])[CH:21]=1>C(O)(=O)C>[Cl:15][CH2:14][C:13]1[N:12]=[C:11]2[CH2:10][C:9]3[N:8]=[CH:7][C:6]([C:17]#[N:18])=[C:5]([NH:19][C:20]4[CH:21]=[C:22]([O:30][CH3:31])[C:23]([O:28][CH3:29])=[C:24]([O:26][CH3:27])[CH:25]=4)[C:4]=3[CH:3]=[C:2]2[N:1]=1

Participants

3

Reactant 1

HCID 21956470HCID 21956470, compound

Product 1

HCID 69372248HCID 69372248, compound

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

A of 0.11 g (0.25 mmol) sample of product from Example 46 in 3.0 mL of glacial acetic acid is heated at 100° C. for 15 minutes, then cooled to room temperature. Following evaporation of the solvent in vacuo, the residue is suspended in water and neutralized with solid sodium carbonate. The solid is collected by filtration, washed with water and dried to yield 0.1 g of 2-(chloromethyl)-8-(3,4,5-trimethoxyanilino)imidazo[4,5-g]quinoline-7-carbonitrile as a yellow solid.

Workup

  1. customevaporation of the solvent in vacuo
  2. filtrationThe solid is collected by filtration
  3. washwashed with water
  4. customdried

Sources & evidence

ORD record
ord-b826d3a3dbf34cc4b4612cc5617f167a
Source dataset
uspto-grants-2003_10
Patent number
US06638929B2

Reaction notes

Loading…