HCID 21956470, compound → HCID 69372248, compound

Participants

Reaction Steps

A of 0.11 g (0.25 mmol) sample of product from Example 46 in 3.0 mL of glacial acetic acid is heated at 100° C. for 15 minutes, then cooled to room temperature. Following evaporation of the solvent in vacuo, the residue is suspended in water and neutralized with solid sodium carbonate. The solid is collected by filtration, washed with water and dried to yield 0.1 g of 2-(chloromethyl)-8-(3,4,5-trimethoxyanilino)imidazo[4,5-g]quinoline-7-carbonitrile as a yellow solid.

Provenance & Evidence