反应详情

A mixture of 2.10 g (11.0 mmol) of 4-hydroxybenzo[4,5]furo[3,2-b]pyridine-3-carbonitrile in 15 mL of phosphorous oxychloride is heated at reflux temperature for 1.5 hours, then cooled to room temperature. Hexane is added and the solid is collected by filtration, dissolved in ethyl acetate and washed with cold 1 N NaOH. The organic layer is dried over sodium sulfate, filtered through a pad of diatomaceous earth and concentrated in vacuo to give 1.55 g (65%) of a red solid, mp 229-231° C.

1. temperatureis heated
2. temperatureat reflux temperature for 1.5 hours
3. filtrationthe solid is collected by filtration
4. dissolutiondissolved in ethyl acetate
5. washwashed with cold 1 N NaOH
6. dry with materialThe organic layer is dried over sodium sulfate
7. filtrationfiltered through a pad of diatomaceous earth
8. concentrationconcentrated in vacuo