HRID989356

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID78373

Methanamine, 1,1-dimethoxy-N,N-dimethyl-

C5H13NO2

HCID9858408

未命名化合物

HCID11594979

未命名化合物

PRODUCTS

生成物

结构：CCOC(=O)c1cc2cc(OCCCl)c(OC)cc2cc1/N=C/N(C)C

HCID178468532

未命名化合物

结构：CCOC(=O)c1cc2cc(OC)c(OCCCl)cc2cc1/N=C/N(C)C

HCID178468534

未命名化合物

PROCEDURE

实验过程

A 648 mg portion of ethyl 3-amino-7-(2-chloroethoxy)-6-methoxy-2-naphthoate and ethyl 3-amino-6-(2-chloroethoxy)-7-methoxy-2-naphthoate (1:1 mixture) and 5 mL of dimethylformamide dimethylacetal is heated to reflux using an oil bath. The reaction is kept at reflux overnight. Solvent is removed in vacuo to provide crude ethyl 6-(2-chloroethoxy)-3-{[(E)-(dimethylamino)methylidene]amino}-7-methoxy-2-naphthoate and ethyl 7-(2-chloroethoxy)-3-{[(E)-(dimethylamino)-methylidene]amino}-6-methoxy-2-naphthoate (1:1 mixture) as a dark red mixture.

WORKUP

后处理

temperatureto reflux
temperatureat reflux overnight
customSolvent is removed in vacuo

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-6303f9da60da4f73b0ed36cf414ac105
来源数据集: uspto-grants-2003_10
DOI: 10.6084/m9.figshare.5104873.v1
专利: US06638929B2
来源说明: uspto-grants-2003_10

反应 SMILES

[NH2:1][C:2]1[C:3]([C:18]([O:20][CH2:21][CH3:22])=[O:19])=[CH:4][C:5]2[C:10]([CH:11]=1)=[CH:9][C:8]([O:12][CH3:13])=[C:7]([O:14][CH2:15][CH2:16][Cl:17])[CH:6]=2.[NH2:23][C:24]1[C:25]([C:40]([O:42][CH2:43][CH3:44])=[O:41])=[CH:26][C:27]2[C:32]([CH:33]=1)=[CH:31][C:30]([O:34][CH2:35][CH2:36][Cl:37])=[C:29]([O:38][CH3:39])[CH:28]=2.CO[CH:47](OC)[N:48]([CH3:50])[CH3:49]>>[Cl:37][CH2:36][CH2:35][O:34][C:30]1[CH:31]=[C:32]2[C:27](=[CH:28][C:29]=1[O:38][CH3:39])[CH:26]=[C:25]([C:40]([O:42][CH2:43][CH3:44])=[O:41])[C:24](/[N:23]=[CH:47]/[N:48]([CH3:50])[CH3:49])=[CH:33]2.[Cl:17][CH2:16][CH2:15][O:14][C:7]1[CH:6]=[C:5]2[C:10]([CH:11]=[C:2](/[N:1]=[CH:47]/[N:48]([CH3:50])[CH3:49])[C:3]([C:18]([O:20][CH2:21][CH3:22])=[O:19])=[CH:4]2)=[CH:9][C:8]=1[O:12][CH3:13]