Hydrochloric Acid → HCID 18418886, compound

HRID 989643Notes

Reaction equation

HRID 989643 reaction equation
[N:1]1[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[CH2:7][C:8]([OH:10])=[O:9].[ClH:11].[CH3:12]O>>[ClH:11].[N:1]1[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[CH2:7][C:8]([O:10][CH3:12])=[O:9]

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 887MethanolHCID 853182-Pyridineacetic acid

Product 1

HCID 18418886HCID 18418886, compoundYield 100%

Procedure

A solution of 2-(2-pyridinyl)acetic acid (0.50 g, 3 mmol; prepared according to J. Prakt. Chem. 1961, 285, 118) in MeOH (20 mL) was saturated with HCl gas at 0° C., then was allowed to warm to RT. After stirring overnight, the reaction was concentrated under vacuum to afford the title compound (0.54 g, 100%) as a colorless solid: 1H NMR (CDCl3) δ8.90 (br s, 1H), 7.89 (m, 2H), 6.89 (t, J=6.5 Hz, 1H), 6.79 (d, J=8 Hz, 1H), 4.21 (m, 2H), 3.81 (s, 3H).

Workup

  1. concentrationthe reaction was concentrated under vacuum

Sources & evidence

ORD record
ord-fcfe33dd1c7d4666a3322414a1d8d086
Source dataset
uspto-grants-2002_10
Patent number
US06458784B1

Reaction notes

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