HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → N-(2-Amino-5,6,7,8-tetrahydroquinazoline-4-yl)-N-(cyclohexylmethyl)amine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | Cyclohexanemethylamine | HCID 76688 | — |
| Reactant | 4-Chloro-5,6,7,8-tetrahydroquinazolin-2-amine | HCID 13707820 | — |
| Solvent | 1-Butanol | HCID 263 | — |
| Product | N-(2-Amino-5,6,7,8-tetrahydroquinazoline-4-yl)-N-(cyclohexylmethyl)amine | HCID 15896203 | — |
Reaction Steps
A mixture of 4-chloro-5,6,7,8-tetrahydroquinazoline-2-ylamine (107 mg, 0.58 mmol), triethylamine (221 mg, 2.18 mmol), cyclohexylmethylamine (132 mg, 1.17 mmol) and n-butanol (3 ml) was reacted for 4 hours at 80-90° C. According to the post-treatment of Example 1, the object compound was obtained (102 mg, 67.9%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06458798B1 |
| Source dataset | uspto-grants-2002_10 |
| ORD ID | ord-d03cb4197fc14ebd925e1629560506d3 |
| Source note | uspto-grants-2002_10 |