Triethylamine → N-(2-Amino-5,6,7,8-tetrahydroquinazoline-4-yl)-N-(cyclohexylmethyl)amine

HRID 989693Notes

Reaction equation

HRID 989693 reaction equation
Cl[C:2]1[C:11]2[CH2:10][CH2:9][CH2:8][CH2:7][C:6]=2[N:5]=[C:4]([NH2:12])[N:3]=1.C(N(CC)CC)C.[CH:20]1([CH2:26][NH2:27])[CH2:25][CH2:24][CH2:23][CH2:22][CH2:21]1>C(O)CCC>[NH2:12][C:4]1[N:3]=[C:2]([NH:27][CH2:26][CH:20]2[CH2:25][CH2:24][CH2:23][CH2:22][CH2:21]2)[C:11]2[CH2:10][CH2:9][CH2:8][CH2:7][C:6]=2[N:5]=1

Participants

5

Reactant 3

HCID 8471TriethylamineHCID 76688CyclohexanemethylamineHCID 137078204-Chloro-5,6,7,8-tetrahydroquinazolin-2-amine

Product 1

HCID 15896203N-(2-Amino-5,6,7,8-tetrahydroquinazoline-4-yl)-N-(cyclohexylmethyl)amine

Reagents, catalysts & solvents 1

HCID 2631-ButanolSolvent

Procedure

A mixture of 4-chloro-5,6,7,8-tetrahydroquinazoline-2-ylamine (107 mg, 0.58 mmol), triethylamine (221 mg, 2.18 mmol), cyclohexylmethylamine (132 mg, 1.17 mmol) and n-butanol (3 ml) was reacted for 4 hours at 80-90° C. According to the post-treatment of Example 1, the object compound was obtained (102 mg, 67.9%).

Workup

  1. customwas reacted for 4 hours at 80-90° C
  2. customthe object compound was obtained (102 mg, 67.9%)

Sources & evidence

ORD record
ord-d03cb4197fc14ebd925e1629560506d3
Source dataset
uspto-grants-2002_10
Patent number
US06458798B1

Reaction notes

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