HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → HCID 15896204, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | Ethyl DL-leucinate hydrochloride | HCID 2769341 | — |
| Reactant | 4-Chloro-5,6,7,8-tetrahydroquinazolin-2-amine | HCID 13707820 | — |
| Solvent | 1-Butanol | HCID 263 | — |
| Product | HCID 15896204 | HCID 15896204 | — |
Reaction Steps
A mixture of 4-chloro-5,6,7,8-tetrahydroquinazoline-2-ylamine (117 mg, 0.64 mmol), triethylamine (259 mg, 2.56 mmol), dl-leucine ethyl ester hydrochloride (250 mg, 1.28 mmol) and n-butanol (2 ml) was reacted for 6 hours at 80-90° C. According to the post-treatment of Example 1, the object compound was obtained (104.3 mg, 72.1%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06458798B1 |
| Source dataset | uspto-grants-2002_10 |
| ORD ID | ord-f4605cc411a248eaae9d6f848ef818c5 |
| Source note | uspto-grants-2002_10 |