Triethylamine → HCID 15896204, compound

HRID 989694Notes

Reaction equation

HRID 989694 reaction equation
Cl[C:2]1[C:11]2[CH2:10][CH2:9][CH2:8][CH2:7][C:6]=2[N:5]=[C:4]([NH2:12])[N:3]=1.C(N(CC)CC)C.Cl.[CH2:21]([O:23][C:24](=[O:31])[CH:25]([CH2:27][CH:28]([CH3:30])[CH3:29])[NH2:26])[CH3:22]>C(O)CCC>[CH2:21]([O:23][C:24](=[O:31])[CH:25]([NH:26][C:2]1[C:11]2[CH2:10][CH2:9][CH2:8][CH2:7][C:6]=2[N:5]=[C:4]([NH2:12])[N:3]=1)[CH2:27][CH:28]([CH3:29])[CH3:30])[CH3:22]

Participants

5

Reactant 3

HCID 8471TriethylamineHCID 2769341Ethyl DL-leucinate hydrochlorideHCID 137078204-Chloro-5,6,7,8-tetrahydroquinazolin-2-amine

Product 1

HCID 15896204HCID 15896204, compound

Reagents, catalysts & solvents 1

HCID 2631-ButanolSolvent

Procedure

A mixture of 4-chloro-5,6,7,8-tetrahydroquinazoline-2-ylamine (117 mg, 0.64 mmol), triethylamine (259 mg, 2.56 mmol), dl-leucine ethyl ester hydrochloride (250 mg, 1.28 mmol) and n-butanol (2 ml) was reacted for 6 hours at 80-90° C. According to the post-treatment of Example 1, the object compound was obtained (104.3 mg, 72.1%).

Workup

  1. customwas reacted for 6 hours at 80-90° C
  2. customthe object compound was obtained (104.3 mg, 72.1%)

Sources & evidence

ORD record
ord-f4605cc411a248eaae9d6f848ef818c5
Source dataset
uspto-grants-2002_10
Patent number
US06458798B1

Reaction notes

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