Pentylamine → HCID 12043758, compound

HRID 989700Notes

Reaction equation

HRID 989700 reaction equation
Cl[C:2]1[C:7]([CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH3:13])=[C:6]([CH3:14])[N:5]=[C:4]([NH2:15])[N:3]=1.[CH2:16]([NH2:21])[CH2:17][CH2:18][CH2:19][CH3:20]>>[NH2:15][C:4]1[N:3]=[C:2]([NH:21][CH2:16][CH2:17][CH2:18][CH2:19][CH3:20])[C:7]([CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH3:13])=[C:6]([CH3:14])[N:5]=1

Participants

3

Reactant 2

HCID 8060PentylamineHCID 22313243HCID 22313243, compound

Product 1

HCID 12043758HCID 12043758, compoundYield 87%

Procedure

A mixture of 4-chloro-5-hexyl-6-methylpyrimidine-2-ylamine (1.00 mg, 0.44 mmol) and amylamine (2 ml) was refluxed for 11 hours. The reaction mixture was cooled and the solvent was removed in vacuo. The residue was purified by silica gel column chromatography (MeOH:CHCl3=1:20) to give the object compound (107 mg, 87%) as an oil.

Workup

  1. temperaturewas refluxed for 11 hours
  2. temperatureThe reaction mixture was cooled
  3. customthe solvent was removed in vacuo
  4. customThe residue was purified by silica gel column chromatography (MeOH:CHCl3=1:20)

Sources & evidence

ORD record
ord-2a4a7ac17b0b42a4b772a64fc1eadc20
Source dataset
uspto-grants-2002_10
Patent number
US06458798B1

Reaction notes

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