Pentylamine → HCID 12043759, compound

HRID 989701Notes

Reaction equation

HRID 989701 reaction equation
Cl[C:2]1[C:3]2[CH2:12][O:11][CH2:10][CH2:9][C:4]=2[N:5]=[C:6]([NH2:8])[N:7]=1.[CH2:13]([NH2:18])[CH2:14][CH2:15][CH2:16][CH3:17]>>[NH2:8][C:6]1[N:7]=[C:2]([NH:18][CH2:13][CH2:14][CH2:15][CH2:16][CH3:17])[C:3]2[CH2:12][O:11][CH2:10][CH2:9][C:4]=2[N:5]=1

Participants

3

Reactant 2

HCID 8060PentylamineHCID 22313253HCID 22313253, compound

Product 1

HCID 12043759HCID 12043759, compoundYield 59%

Procedure

A mixture of 4-chloro-7,8-dihydro-5H-pyrano[4,3-d]pyrimidine-2-ylamine (29.3 mg, 0.158 mmol) and amylamine (1.0 ml) was refluxed for 2.5 hours. After reaction, the procedure according to pro-treatment of Example 7 was carried out to give the object compound (22.3 mg, 59%).

Workup

  1. temperaturewas refluxed for 2.5 hours
  2. customAfter reaction

Sources & evidence

ORD record
ord-ea9967d56962415795864ef0bea23854
Source dataset
uspto-grants-2002_10
Patent number
US06458798B1

Reaction notes

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