Phosphorus oxychloride → HCID 2753178, Verbindung

HRID 989713Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 989713
[NH2:1][C:2]1[N:7]=[C:6](O)[C:5]([CH2:9][CH2:10][CH2:11][CH3:12])=[C:4]([CH3:13])[N:3]=1.P(Cl)(Cl)([Cl:16])=O>>[CH2:9]([C:5]1[C:6]([Cl:16])=[N:7][C:2]([NH2:1])=[N:3][C:4]=1[CH3:13])[CH2:10][CH2:11][CH3:12]

Komponenten

3

Edukt 2

HCID 24813Phosphorus oxychlorideHCID 178441161HCID 178441161, Verbindung

Produkt 1

HCID 2753178HCID 2753178, VerbindungAusbeute 29 %

Versuchsvorschrift

2-Amino-5-butyl-6-methylpyrimidine-4-ol (1.0 g, 5.52 mmol) and phosphorus oxychloride (12 ml) were refluxed for 3 hours. The solvent was removed in vacuo and the residue was purified by silica gel column chromatography(n-hexane: ethyl acetate=2:1) to give the object compound (325 mg, 29%).

Aufarbeitung

  1. customThe solvent was removed in vacuo
  2. customthe residue was purified by silica gel column chromatography(n-hexane: ethyl acetate=2:1)

Quellen und Nachweise

ORD-Eintrag
ord-67e2d5589a28437cb12f31a8139ee0ca
Quelldatensatz
uspto-grants-2002_10
Patentnummer
US06458798B1

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