Phosphorus oxychloride → HCID 22313243, compound

HRID 989714Notes

Reaction equation

[NH2:1][C:2]1[N:7]=[C:6](O)[C:5]([CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH3:14])=[C:4]([CH3:15])[N:3]=1.P(Cl)(Cl)([Cl:18])=O>>[Cl:18][C:6]1[C:5]([CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH3:14])=[C:4]([CH3:15])[N:3]=[C:2]([NH2:1])[N:7]=1

Participants

Reactant 2

HCID 24813Phosphorus oxychloride

HCID 178442391HCID 178442391, compound

Product 1

HCID 22313243HCID 22313243, compoundYield 18%

Procedure

By using ethyl 2-acetyloctanoate (6.43 g, 30 mmol) as a starting material and according to the method of Reference-example 2, there was obtained 2-amino-5-hexyl-6-methylpyrimidine-4-ol (4.70 g, 74%). By reacting the obtained 2-amino-5-hexyl-6-methylpyrimidine-4-ol (1 g, 4.78 mmol) and phosphorous oxychloride (12 ml), there was obtained the object compound (196 mg, 18%).

Sources & evidence

ORD record: ord-d12b1cc603134455a5e67fa1c2862f1a
Source dataset: uspto-grants-2002_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06458798B1

Reaction notes

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