Phosphorus oxychloride → HCID 21813589, compound

HRID 989720Notes

Reaction equation

HRID 989720 reaction equation
[NH2:1][C:2]1[N:7]=[C:6](O)[C:5]([CH2:9][CH2:10][C:11]#[N:12])=[C:4]([CH3:13])[N:3]=1.P(Cl)(Cl)([Cl:16])=O>>[NH2:1][C:2]1[N:7]=[C:6]([Cl:16])[C:5]([CH2:9][CH2:10][C:11]#[N:12])=[C:4]([CH3:13])[N:3]=1

Participants

3

Reactant 2

HCID 24813Phosphorus oxychlorideHCID 178433375HCID 178433375, compound

Product 1

HCID 21813589HCID 21813589, compoundYield 48%

Procedure

A mixture of 3-(2-amino-4-hydroxy-6-methylpyrimidine-5-yl)propanenitrile (2 g, 11.2 mmol) and phosphorous oxychloride (13 ml) was kept at 90° C. for 5 hours. The procedure according to pro-treatment of Reference-example 6 was carried out to give the object compound (1.06 g, 48%).

Sources & evidence

ORD record
ord-3bd38bb76ff945bfaf9a9444cf9a36a5
Source dataset
uspto-grants-2002_10
Patent number
US06458798B1

Reaction notes

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