Ethyl alpha-benzylacetoacetate → HCID 178433370, compound

HRID 989723Notes

Reaction equation

HRID 989723 reaction equation
[CH2:1]([CH:8]([C:14](=O)[CH3:15])[C:9](OCC)=[O:10])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.C(=O)(O)O.[NH2:21][C:22]([NH2:24])=[NH:23]>C(O)C>[NH2:24][C:22]1[N:23]=[C:9]([OH:10])[C:8]([CH2:1][C:2]2[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=2)=[C:14]([CH3:15])[N:21]=1

Participants

4

Reactant 2

HCID 246929Ethyl alpha-benzylacetoacetateHCID 286947Carbonic acid-guanidine (1:1)

Product 1

HCID 178433370HCID 178433370, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A mixture of ethyl 2-benzyl-3-oxobutanoate (6 g, 27.2 mmol), guanidine carbonate (2.94 g, 16.3 mmol) and ethanol (20 ml) was refluxed for 10 hours. After cooling, the precipitate was filtered and washed with water, ethanol and ether in order, to the object compound (3.62 g, 61.7%).

Workup

  1. temperaturewas refluxed for 10 hours
  2. temperatureAfter cooling
  3. filtrationthe precipitate was filtered
  4. washwashed with water, ethanol and ether in order, to the object compound (3.62 g, 61.7%)

Sources & evidence

ORD record
ord-5332110f54a446c096392bcf4a531351
Source dataset
uspto-grants-2002_10
Patent number
US06458798B1

Reaction notes

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