反应详情

20.5 g (144 mmol) of 3-nonanone are initially charged in 200 ml of methanol, 5.45 g (144 mmol) of sodium borohydride are added a little at a time at room temperature and the mixture is stirred overnight. The solvent is removed under reduced pressure and the mixture is then acidified and extracted with dichloromethane. The organic phase is dried over sodium sulphate. Removal of the solvent gives 20 g (96%) of a colourless oil.

1. customThe solvent is removed under reduced pressure
2. extractionextracted with dichloromethane
3. dry with materialThe organic phase is dried over sodium sulphate
4. customRemoval of the solvent