Potassium Carbonate → HCID 23449123, compound

HRID 989830Notes

Reaction equation

HRID 989830 reaction equation
C([O:4][CH2:5][C:6]([C:8]1[N:9]=[CH:10][N:11]2[CH:15]=[CH:14][S:13][C:12]=12)=[O:7])(=O)C.C(=O)([O-])[O-].[K+].[K+]>CO.O>[OH:4][CH2:5][C:6]([C:8]1[N:9]=[CH:10][N:11]2[CH:15]=[CH:14][S:13][C:12]=12)=[O:7]

Participants

5

Reactant 2

HCID 11430Potassium CarbonateHCID 23449267HCID 23449267, compound

Product 1

HCID 23449123HCID 23449123, compoundYield 94.1%

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 962WaterSolvent

Procedure

7-Acetoxyacetylimidazo[5,1-b]thiazole (24.6 mg) was dissolved in 2 ml of methanol and 0.5 ml of water. Potassium carbonate (17.3 mg) was added under ice cooling to the solution. The mixture was stirred for 45 min. Methanol was removed by distillation under the reduced pressure. Water (10 ml) was added to the residue, followed by extraction five times with dichloromethane. The extract was dried over anhydrous magnesium sulfate, and then filtered. The solvent was removed by distillation under the reduced pressure to give 18.8 mg of 7-hydroxyacetylimidazo[5,1-b]thiazole.

Workup

  1. customMethanol was removed by distillation under the reduced pressure
  2. additionWater (10 ml) was added to the residue
  3. extractionfollowed by extraction five times with dichloromethane
  4. dry with materialThe extract was dried over anhydrous magnesium sulfate
  5. filtrationfiltered
  6. customThe solvent was removed by distillation under the reduced pressure

Sources & evidence

ORD record
ord-6f48d1cfa46546eb908b70c5666a043d
Source dataset
uspto-grants-2002_10
Patent number
US06458780B1

Reaction notes

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