Ammonia methanol → 7-Sulfamoylimidazo[5,1-b]thiazole

HRID 989847Notes

Reaction equation

HRID 989847 reaction equation
[NH3:1].CO.Cl[S:5]([C:8]1[N:9]=[CH:10][N:11]2[CH:15]=[CH:14][S:13][C:12]=12)(=[O:7])=[O:6]>C1COCC1>[S:5]([C:8]1[N:9]=[CH:10][N:11]2[CH:15]=[CH:14][S:13][C:12]=12)(=[O:7])(=[O:6])[NH2:1]

Participants

4

Reactant 2

HCID 21705897Ammonia methanolHCID 234490387-Chlorosulfonylimidazo[5,1-b]thiazole

Product 1

HCID 234491397-Sulfamoylimidazo[5,1-b]thiazole

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

A 2 M ammonia/methanol solution (4 ml) was added to a solution of 0.44 g of 7-chlorosulfonylimidazo[5,1-b]thiazole in 10 ml of THF. The mixture was stirred at room temperature for 12 hr. The reaction mixture was concentrated. The residue was purified by column chromatography on silica gel (dichloromethane:methanol=10:1) to give 0.34 g of 7-sulfamoylimidazo[5,1-b]thiazole.

Workup

  1. concentrationThe reaction mixture was concentrated
  2. customThe residue was purified by column chromatography on silica gel (dichloromethane:methanol=10:1)

Sources & evidence

ORD record
ord-68e035aa4b924d19b3ebc853d3385982
Source dataset
uspto-grants-2002_10
Patent number
US06458780B1

Reaction notes

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