Triphenylphosphine → [2-(3-Ethoxycarbonyl-2-phenylpropyl)-1,3-oxazol-4-yl]methyltriphenylphosphonium bromide

Participants

Reaction Steps

A solution of ethyl (±)-4-(4-bromomethyl-1,3-oxazol-2-yl)-3-phenylbutanoate (1.0 g, 2.84 mmole) and PPh3 (745 mg, 2.84 mmole) in dry CH3CN (10 mL) was heated at reflux under N2. After 3 hr, the mixture was cooled to RT and concentrated under reduced pressure. The residue was triturated with Et2O (10 mL) to give the title compound (1.66 g, 95%) as a white powder: MS (ES) m/e 535 (M+H)+.

Provenance & Evidence