HRID989901

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID11776

Triphenylphosphine

C18H15P

HCID23389064

未命名化合物

PRODUCTS

生成物

结构：CCOC(=O)CC(Cc1nc(C[P+](c2ccccc2)(c2ccccc2)c2ccccc2)co1)c1ccccc1.[Br-]

HCID18419548

未命名化合物

收率 95.1%

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID6342

Acetonitrile

C2H3N

PROCEDURE

实验过程

A solution of ethyl (±)-4-(4-bromomethyl-1,3-oxazol-2-yl)-3-phenylbutanoate (1.0 g, 2.84 mmole) and PPh3 (745 mg, 2.84 mmole) in dry CH3CN (10 mL) was heated at reflux under N2. After 3 hr, the mixture was cooled to RT and concentrated under reduced pressure. The residue was triturated with Et2O (10 mL) to give the title compound (1.66 g, 95%) as a white powder: MS (ES) m/e 535 (M+H)+.

WORKUP

后处理

temperatureat reflux under N2
concentrationconcentrated under reduced pressure
customThe residue was triturated with Et2O (10 mL)

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-77f61c63de6a4ed0b77b4e4c07a242e2
来源数据集: uspto-grants-2002_10
DOI: 10.6084/m9.figshare.5104873.v1
专利: US06458814B1
来源说明: uspto-grants-2002_10

反应 SMILES

[Br:1][CH2:2][C:3]1[N:4]=[C:5]([CH2:8][CH:9]([C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=2)[CH2:10][C:11]([O:13][CH2:14][CH3:15])=[O:12])[O:6][CH:7]=1.[CH:22]1[CH:27]=[CH:26][C:25]([P:28]([C:35]2[CH:40]=[CH:39][CH:38]=[CH:37][CH:36]=2)[C:29]2[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=2)=[CH:24][CH:23]=1>CC#N>[Br-:1].[CH2:14]([O:13][C:11]([CH2:10][CH:9]([C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1)[CH2:8][C:5]1[O:6][CH:7]=[C:3]([CH2:2][P+:28]([C:29]2[CH:30]=[CH:31][CH:32]=[CH:33][CH:34]=2)([C:35]2[CH:40]=[CH:39][CH:38]=[CH:37][CH:36]=2)[C:25]2[CH:24]=[CH:23][CH:22]=[CH:27][CH:26]=2)[N:4]=1)=[O:12])[CH3:15]