Ethanol → HCID 22035746, compound

HRID 989933Notes

Reaction equation

HRID 989933 reaction equation
[OH:1][C:2]([CH3:7])([CH3:6])[C:3]([OH:5])=[O:4].[CH3:8][O:9][C:10]1[CH:17]=[CH:16][C:13]([CH2:14]Cl)=[CH:12][CH:11]=1.C(O)C>ClCCl>[OH:1][C:2]([CH3:7])([CH3:6])[C:3]([O:5][CH2:14][C:13]1[CH:16]=[CH:17][C:10]([O:9][CH3:8])=[CH:11][CH:12]=1)=[O:4]

Participants

5

Reactant 3

HCID 702EthanolHCID 116712-Hydroxyisobutyric acidHCID 699934-Methyloxybenzyl chloride

Product 1

HCID 22035746HCID 22035746, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

2-hydroxy isobutyric acid (1.56 g) was esterified by alkylation with 4-methoxybenzyl chloride by the method described in Example A-I-1, step a). The title compound (2.65 g) was obtained after silica gel column chromatography (0, 1, 2% ethanol in dichloromethane). Rf (2%MeOH/CHCl3) 0.45.

Sources & evidence

ORD record
ord-9312de923c69468ebce16aa06cfac8d9
Source dataset
uspto-grants-2002_10
Patent number
US06458772B1

Reaction notes

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